Extensive phenotypic characterization of a new transgenic mouse reveals pleiotropic perturbations in physiology due to mesenchymal hGH minigene expression

The human growth hormone (hGH) minigene used for transgene stabilization in mice has been recently identified to be locally expressed in the tissues where transgenes are active and associated with phenotypic alterations. Here we extend these findings by analyzing the effect of the hGH minigene in Tg...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Pubblicato in:Sci Rep
Autori principali: Kaklamanos, Aimilios, Rozman, Jan, Roulis, Manolis, Karagianni, Niki, Armaka, Maria, Wu, Moya, Brachthäuser, Laura, Calzada-Wack, Julia, Horsch, Marion, Beckers, Johannes, Rathkolb, Birgit, Adler, Thure, Neff, Frauke, Wolf, Eckhard, Gailus-Durner, Valerie, Fuchs, Helmut, de Angelis, Martin Hrabe, Kollias, George
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2017
Soggetti:
Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5445072/
https://ncbi.nlm.nih.gov/pubmed/28546545
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-02581-8
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi