Extensive phenotypic characterization of a new transgenic mouse reveals pleiotropic perturbations in physiology due to mesenchymal hGH minigene expression

The human growth hormone (hGH) minigene used for transgene stabilization in mice has been recently identified to be locally expressed in the tissues where transgenes are active and associated with phenotypic alterations. Here we extend these findings by analyzing the effect of the hGH minigene in Tg...

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Detaylı Bibliyografya
Yayımlandı:Sci Rep
Asıl Yazarlar: Kaklamanos, Aimilios, Rozman, Jan, Roulis, Manolis, Karagianni, Niki, Armaka, Maria, Wu, Moya, Brachthäuser, Laura, Calzada-Wack, Julia, Horsch, Marion, Beckers, Johannes, Rathkolb, Birgit, Adler, Thure, Neff, Frauke, Wolf, Eckhard, Gailus-Durner, Valerie, Fuchs, Helmut, de Angelis, Martin Hrabe, Kollias, George
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group UK 2017
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5445072/
https://ncbi.nlm.nih.gov/pubmed/28546545
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-02581-8
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