Standardized, systemic phenotypic analysis reveals kidney dysfunction as main alteration of Kctd1(I27N) mutant mice

BACKGROUND: Increased levels of blood plasma urea were used as phenotypic parameter for establishing novel mouse models for kidney diseases on the genetic background of C3H inbred mice in the phenotype-driven Munich ENU mouse mutagenesis project. The phenotypically dominant mutant line HST014 was es...

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Udgivet i:J Biomed Sci
Main Authors: Kumar, Sudhir, Rathkolb, Birgit, Sabrautzki, Sibylle, Krebs, Stefan, Kemter, Elisabeth, Becker, Lore, Beckers, Johannes, Bekeredjian, Raffi, Brommage, Robert, Calzada-Wack, Julia, Garrett, Lillian, Hölter, Sabine M., Horsch, Marion, Klingenspor, Martin, Klopstock, Thomas, Moreth, Kristin, Neff, Frauke, Rozman, Jan, Fuchs, Helmut, Gailus-Durner, Valérie, Hrabe de Angelis, Martin, Wolf, Eckhard, Aigner, Bernhard
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2017
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Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5559776/
https://ncbi.nlm.nih.gov/pubmed/28818080
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12929-017-0365-5
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