Keratins regulate colonic epithelial cell differentiation through the Notch1 signalling pathway

Keratins (K) are intermediate filament proteins important in stress protection and mechanical support of epithelial tissues. K8, K18 and K19 are the main colonic keratins, and K8-knockout (K8(−/−)) mice display a keratin dose-dependent hyperproliferation of colonic crypts and a colitis-phenotype. Ho...

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Detalhes bibliográficos
Publicado no:Cell Death Differ
Main Authors: Lähdeniemi, Iris A K, Misiorek, Julia O, Antila, Christian J M, Landor, Sebastian K-J, Stenvall, Carl-Gustaf A, Fortelius, Lina E, Bergström, Linda K, Sahlgren, Cecilia, Toivola, Diana M
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Original Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5442467/
https://ncbi.nlm.nih.gov/pubmed/28475172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2017.28
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