Keratins regulate colonic epithelial cell differentiation through the Notch1 signalling pathway

Keratins (K) are intermediate filament proteins important in stress protection and mechanical support of epithelial tissues. K8, K18 and K19 are the main colonic keratins, and K8-knockout (K8(−/−)) mice display a keratin dose-dependent hyperproliferation of colonic crypts and a colitis-phenotype. Ho...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Cell Death Differ
Egile Nagusiak: Lähdeniemi, Iris A K, Misiorek, Julia O, Antila, Christian J M, Landor, Sebastian K-J, Stenvall, Carl-Gustaf A, Fortelius, Lina E, Bergström, Linda K, Sahlgren, Cecilia, Toivola, Diana M
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Nature Publishing Group 2017
Gaiak:
Original Paper
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5442467/
https://ncbi.nlm.nih.gov/pubmed/28475172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2017.28
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