Keratins regulate colonic epithelial cell differentiation through the Notch1 signalling pathway

Keratins (K) are intermediate filament proteins important in stress protection and mechanical support of epithelial tissues. K8, K18 and K19 are the main colonic keratins, and K8-knockout (K8(−/−)) mice display a keratin dose-dependent hyperproliferation of colonic crypts and a colitis-phenotype. Ho...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Cell Death Differ
Prif Awduron: Lähdeniemi, Iris A K, Misiorek, Julia O, Antila, Christian J M, Landor, Sebastian K-J, Stenvall, Carl-Gustaf A, Fortelius, Lina E, Bergström, Linda K, Sahlgren, Cecilia, Toivola, Diana M
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group 2017
Pynciau:
Original Paper
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5442467/
https://ncbi.nlm.nih.gov/pubmed/28475172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2017.28
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