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Keratin 8 absence down-regulates colonocyte HMGCS2 and modulates colonic ketogenesis and energy metabolism

Simple-type epithelial keratins are intermediate filament proteins important for mechanical stability and stress protection. Keratin mutations predispose to human liver disorders, whereas their roles in intestinal diseases are unclear. Absence of keratin 8 (K8) in mice leads to colitis, decreased Na...

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Bibliografske podrobnosti
izdano v:Mol Biol Cell
Main Authors: Helenius, Terhi O., Misiorek, Julia O., Nyström, Joel H., Fortelius, Lina E., Habtezion, Aida, Liao, Jian, Asghar, M. Nadeem, Zhang, Haiyan, Azhar, Salman, Omary, M. Bishr, Toivola, Diana M.
Format: Artigo
Jezik:Inglês
Izdano: The American Society for Cell Biology 2015
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4462946/
https://ncbi.nlm.nih.gov/pubmed/25904331
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E14-02-0736
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