Absence of keratin 8 or 18 promotes antimitochondrial autoantibody formation in aging male mice

Human mutations in keratin 8 (K8) and keratin 18 (K18), the intermediate filament proteins of hepatocytes, predispose to several liver diseases. K8-null mice develop chronic liver injury and fragile hepatocytes, dysfunctional mitochondria, and Th2-type colitis. We tested the hypothesis that autoanti...

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Vydáno v:FASEB J
Hlavní autoři: Toivola, Diana M., Habtezion, Aida, Misiorek, Julia O., Zhang, Linxing, Nyström, Joel H., Sharpe, Orr, Robinson, William H., Kwan, Raymond, Omary, M. Bishr
Médium: Artigo
Jazyk:Inglês
Vydáno: Federation of American Societies for Experimental Biology 2015
Témata:
Research Communication
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4653051/
https://ncbi.nlm.nih.gov/pubmed/26399787
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.14-269795
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