Chargement en cours...
Mutation of caspase-digestion sites in keratin 18 interferes with filament reorganization, and predisposes to hepatocyte necrosis and loss of membrane integrity
Keratin 18 (K18 or KRT18) undergoes caspase-mediated cleavage during apoptosis, the significance of which is poorly understood. Here, we mutated the two caspase-cleavage sites (D238E and D397E) in K18 (K18-DE), followed by transgenic overexpression of the resulting mutant. We found that K18-DE mice...
Enregistré dans:
| Auteurs principaux: | , , , , |
|---|---|
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
The Company of Biologists
2014
|
| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3970558/ https://ncbi.nlm.nih.gov/pubmed/24463813 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.138479 |
| Tags: |
Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!
|