Mutation of caspase-digestion sites in keratin 18 interferes with filament reorganization, and predisposes to hepatocyte necrosis and loss of membrane integrity

Keratin 18 (K18 or KRT18) undergoes caspase-mediated cleavage during apoptosis, the significance of which is poorly understood. Here, we mutated the two caspase-cleavage sites (D238E and D397E) in K18 (K18-DE), followed by transgenic overexpression of the resulting mutant. We found that K18-DE mice...

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Bibliographic Details
Main Authors: Weerasinghe, Sujith V. W., Ku, Nam-On, Altshuler, Peter J., Kwan, Raymond, Omary, M. Bishr
Format: Artigo
Language:Inglês
Published: The Company of Biologists 2014
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3970558/
https://ncbi.nlm.nih.gov/pubmed/24463813
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.138479
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