Keratins regulate colonic epithelial cell differentiation through the Notch1 signalling pathway

Keratins (K) are intermediate filament proteins important in stress protection and mechanical support of epithelial tissues. K8, K18 and K19 are the main colonic keratins, and K8-knockout (K8(−/−)) mice display a keratin dose-dependent hyperproliferation of colonic crypts and a colitis-phenotype. Ho...

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Bibliografiske detaljer
Udgivet i:Cell Death Differ
Main Authors: Lähdeniemi, Iris A K, Misiorek, Julia O, Antila, Christian J M, Landor, Sebastian K-J, Stenvall, Carl-Gustaf A, Fortelius, Lina E, Bergström, Linda K, Sahlgren, Cecilia, Toivola, Diana M
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2017
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Original Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5442467/
https://ncbi.nlm.nih.gov/pubmed/28475172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2017.28
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