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Keratins regulate colonic epithelial cell differentiation through the Notch1 signalling pathway
Keratins (K) are intermediate filament proteins important in stress protection and mechanical support of epithelial tissues. K8, K18 and K19 are the main colonic keratins, and K8-knockout (K8(−/−)) mice display a keratin dose-dependent hyperproliferation of colonic crypts and a colitis-phenotype. Ho...
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| Vydáno v: | Cell Death Differ |
|---|---|
| Hlavní autoři: | , , , , , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Nature Publishing Group
2017
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5442467/ https://ncbi.nlm.nih.gov/pubmed/28475172 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2017.28 |
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