Sirt1 carboxyl-domain is an ATP-repressible domain that is transferrable to other proteins

Sirt1 is an NAD(+)-dependent protein deacetylase that regulates many physiological functions, including stress resistance, adipogenesis, cell senescence and energy production. Sirt1 can be activated by energy deprivation, but the mechanism is poorly understood. Here, we report that Sirt1 is negative...

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Vydáno v:Nat Commun
Hlavní autoři: Kang, Hyeog, Oka, Shinichi, Lee, Duck-Yeon, Park, Junhong, Aponte, Angel M., Jung, Young-Sang, Bitterman, Jacob, Zhai, Peiyong, He, Yi, Kooshapur, Hamed, Ghirlando, Rodolfo, Tjandra, Nico, Lee, Sean B., Kim, Myung K., Sadoshima, Junichi, Chung, Jay H.
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2017
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5440690/
https://ncbi.nlm.nih.gov/pubmed/28504272
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms15560
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