Sirt1 carboxyl-domain is an ATP-repressible domain that is transferrable to other proteins

Sirt1 is an NAD(+)-dependent protein deacetylase that regulates many physiological functions, including stress resistance, adipogenesis, cell senescence and energy production. Sirt1 can be activated by energy deprivation, but the mechanism is poorly understood. Here, we report that Sirt1 is negative...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Kang, Hyeog, Oka, Shinichi, Lee, Duck-Yeon, Park, Junhong, Aponte, Angel M., Jung, Young-Sang, Bitterman, Jacob, Zhai, Peiyong, He, Yi, Kooshapur, Hamed, Ghirlando, Rodolfo, Tjandra, Nico, Lee, Sean B., Kim, Myung K., Sadoshima, Junichi, Chung, Jay H.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5440690/
https://ncbi.nlm.nih.gov/pubmed/28504272
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms15560
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