MyoD binds cooperatively to two sites in a target enhancer sequence: occupancy of two sites is required for activation.

MyoD is a master regulatory gene for myogenesis. Its product, the MyoD protein, appears to act by binding to muscle-specific enhancer sequences. We show that MyoD binds cooperatively to two sites in the muscle-specific creatine kinase enhancer; this is dramatically reflected in dissociation-rate mea...

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Bibliographic Details
Main Authors: Weintraub, H, Davis, R, Lockshon, D, Lassar, A
Format: Artigo
Language:Inglês
Published: 1990
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC54379/
https://ncbi.nlm.nih.gov/pubmed/2377600
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