MyoD binds cooperatively to two sites in a target enhancer sequence: occupancy of two sites is required for activation.
MyoD is a master regulatory gene for myogenesis. Its product, the MyoD protein, appears to act by binding to muscle-specific enhancer sequences. We show that MyoD binds cooperatively to two sites in the muscle-specific creatine kinase enhancer; this is dramatically reflected in dissociation-rate mea...
保存先:
| 出版年: | Proc Natl Acad Sci U S A |
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| 主要な著者: | , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
National Academy of Sciences
1990
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC54379/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2377600/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.87.15.5623 |
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