Inhibition of O-GlcNAcase leads to elevation of O-GlcNAc tau and reduction of tauopathy and cerebrospinal fluid tau in rTg4510 mice

BACKGROUND: Hyperphosphorylation of microtubule-associated protein tau is a distinct feature of neurofibrillary tangles (NFTs) that are the hallmark of neurodegenerative tauopathies. O-GlcNAcylation is a lesser known post-translational modification of tau that involves the addition of N-acetylglucos...

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Detalhes bibliográficos
Publicado no:Mol Neurodegener
Main Authors: Hastings, Nicholas B., Wang, Xiaohai, Song, Lixin, Butts, Brent D., Grotz, Diane, Hargreaves, Richard, Fred Hess, J., Hong, Kwok-Lam Karen, Huang, Cathy Ruey-Ruey, Hyde, Lynn, Laverty, Maureen, Lee, Julie, Levitan, Diane, Lu, Sherry X., Maguire, Maureen, Mahadomrongkul, Veeravan, McEachern, Ernest J., Ouyang, Xuesong, Rosahl, Thomas W., Selnick, Harold, Stanton, Michaela, Terracina, Giuseppe, Vocadlo, David J., Wang, Ganfeng, Duffy, Joseph L., Parker, Eric M., Zhang, Lili
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5437664/
https://ncbi.nlm.nih.gov/pubmed/28521765
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13024-017-0181-0
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