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Tau association with synaptic vesicles causes presynaptic dysfunction

Tau is implicated in more than 20 neurodegenerative diseases, including Alzheimer's disease. Under pathological conditions, Tau dissociates from axonal microtubules and missorts to pre- and postsynaptic terminals. Patients suffer from early synaptic dysfunction prior to Tau aggregate formation,...

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Podrobná bibliografie
Vydáno v:	Nat Commun
Hlavní autoři:	Zhou, Lujia, McInnes, Joseph, Wierda, Keimpe, Holt, Matthew, Herrmann, Abigail G., Jackson, Rosemary J., Wang, Yu-Chun, Swerts, Jef, Beyens, Jelle, Miskiewicz, Katarzyna, Vilain, Sven, Dewachter, Ilse, Moechars, Diederik, De Strooper, Bart, Spires-Jones, Tara L., De Wit, Joris, Verstreken, Patrik
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Nature Publishing Group 2017
Témata:	Article
On-line přístup:	https://ncbi.nlm.nih.gov/pmc/articles/PMC5437271/ https://ncbi.nlm.nih.gov/pubmed/28492240 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms15295
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Tau association with synaptic vesicles causes presynaptic dysfunction

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