Lowering Synaptogyrin-3 expression rescues Tau-induced memory defects and synaptic loss in the presence of microglial activation

Tau is a major driver of neurodegeneration and is implicated in over 20 diseases. Tauopathies are characterized by synaptic loss and neuroinflammation, but it is unclear if these pathological events are causally linked. Tau binds to Synaptogyrin-3 on synaptic vesicles. Here, we interfered with this...

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Detaylı Bibliyografya
Yayımlandı:Neuron
Asıl Yazarlar: Largo-Barrientos, Pablo, Apóstolo, Nuno, Creemers, Eline, Callaerts-Vegh, Zsuzsanna, Swerts, Jef, Davies, Caitlin, McInnes, Joseph, Wierda, Keimpe, De Strooper, Bart, Spires-Jones, Tara, de Wit, Joris, Uytterhoeven, Valerie, Verstreken, Patrik
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Cell Press 2021
Konular:
Report
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7927913/
https://ncbi.nlm.nih.gov/pubmed/33472038
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2020.12.016
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