Reduced synaptic vesicle protein degradation at lysosomes curbs TBC1D24/sky-induced neurodegeneration

Synaptic demise and accumulation of dysfunctional proteins are thought of as common features in neurodegeneration. However, the mechanisms by which synaptic proteins turn over remain elusive. In this paper, we study Drosophila melanogaster lacking active TBC1D24/Skywalker (Sky), a protein that in hu...

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Detaylı Bibliyografya
Yayımlandı:J Cell Biol
Asıl Yazarlar: Fernandes, Ana Clara, Uytterhoeven, Valerie, Kuenen, Sabine, Wang, Yu-Chun, Slabbaert, Jan R., Swerts, Jef, Kasprowicz, Jaroslaw, Aerts, Stein, Verstreken, Patrik
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: The Rockefeller University Press 2014
Konular:
Research Articles
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4242831/
https://ncbi.nlm.nih.gov/pubmed/25422373
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201406026
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