Reduced synaptic vesicle protein degradation at lysosomes curbs TBC1D24/sky-induced neurodegeneration

Synaptic demise and accumulation of dysfunctional proteins are thought of as common features in neurodegeneration. However, the mechanisms by which synaptic proteins turn over remain elusive. In this paper, we study Drosophila melanogaster lacking active TBC1D24/Skywalker (Sky), a protein that in hu...

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Detalhes bibliográficos
Publicado no:J Cell Biol
Main Authors: Fernandes, Ana Clara, Uytterhoeven, Valerie, Kuenen, Sabine, Wang, Yu-Chun, Slabbaert, Jan R., Swerts, Jef, Kasprowicz, Jaroslaw, Aerts, Stein, Verstreken, Patrik
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2014
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Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4242831/
https://ncbi.nlm.nih.gov/pubmed/25422373
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201406026
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