Reduced synaptic vesicle protein degradation at lysosomes curbs TBC1D24/sky-induced neurodegeneration

Synaptic demise and accumulation of dysfunctional proteins are thought of as common features in neurodegeneration. However, the mechanisms by which synaptic proteins turn over remain elusive. In this paper, we study Drosophila melanogaster lacking active TBC1D24/Skywalker (Sky), a protein that in hu...

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Bibliografische gegevens
Gepubliceerd in:J Cell Biol
Hoofdauteurs: Fernandes, Ana Clara, Uytterhoeven, Valerie, Kuenen, Sabine, Wang, Yu-Chun, Slabbaert, Jan R., Swerts, Jef, Kasprowicz, Jaroslaw, Aerts, Stein, Verstreken, Patrik
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: The Rockefeller University Press 2014
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Research Articles
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4242831/
https://ncbi.nlm.nih.gov/pubmed/25422373
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201406026
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