Reduced synaptic vesicle protein degradation at lysosomes curbs TBC1D24/sky-induced neurodegeneration

Synaptic demise and accumulation of dysfunctional proteins are thought of as common features in neurodegeneration. However, the mechanisms by which synaptic proteins turn over remain elusive. In this paper, we study Drosophila melanogaster lacking active TBC1D24/Skywalker (Sky), a protein that in hu...

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Veröffentlicht in:J Cell Biol
Hauptverfasser: Fernandes, Ana Clara, Uytterhoeven, Valerie, Kuenen, Sabine, Wang, Yu-Chun, Slabbaert, Jan R., Swerts, Jef, Kasprowicz, Jaroslaw, Aerts, Stein, Verstreken, Patrik
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Rockefeller University Press 2014
Schlagworte:
Research Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4242831/
https://ncbi.nlm.nih.gov/pubmed/25422373
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201406026
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