Lowering Synaptogyrin-3 expression rescues Tau-induced memory defects and synaptic loss in the presence of microglial activation

Tau is a major driver of neurodegeneration and is implicated in over 20 diseases. Tauopathies are characterized by synaptic loss and neuroinflammation, but it is unclear if these pathological events are causally linked. Tau binds to Synaptogyrin-3 on synaptic vesicles. Here, we interfered with this...

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Publicado en:Neuron
Main Authors: Largo-Barrientos, Pablo, Apóstolo, Nuno, Creemers, Eline, Callaerts-Vegh, Zsuzsanna, Swerts, Jef, Davies, Caitlin, McInnes, Joseph, Wierda, Keimpe, De Strooper, Bart, Spires-Jones, Tara, de Wit, Joris, Uytterhoeven, Valerie, Verstreken, Patrik
Formato: Artigo
Idioma:Inglês
Publicado: Cell Press 2021
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7927913/
https://ncbi.nlm.nih.gov/pubmed/33472038
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2020.12.016
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