Tau association with synaptic vesicles causes presynaptic dysfunction

Tau is implicated in more than 20 neurodegenerative diseases, including Alzheimer's disease. Under pathological conditions, Tau dissociates from axonal microtubules and missorts to pre- and postsynaptic terminals. Patients suffer from early synaptic dysfunction prior to Tau aggregate formation,...

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Udgivet i:Nat Commun
Main Authors: Zhou, Lujia, McInnes, Joseph, Wierda, Keimpe, Holt, Matthew, Herrmann, Abigail G., Jackson, Rosemary J., Wang, Yu-Chun, Swerts, Jef, Beyens, Jelle, Miskiewicz, Katarzyna, Vilain, Sven, Dewachter, Ilse, Moechars, Diederik, De Strooper, Bart, Spires-Jones, Tara L., De Wit, Joris, Verstreken, Patrik
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5437271/
https://ncbi.nlm.nih.gov/pubmed/28492240
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms15295
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