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Modifiers of prion protein biogenesis and recycling identified by a highly parallel endocytosis kinetics assay
The cellular prion protein, PrP(C), is attached by a glycosylphosphatidylinositol anchor to the outer leaflet of the plasma membrane. Its misfolded isoform PrP(Sc) is the causative agent of prion diseases. Conversion of PrP(C) into PrP(Sc) is thought to take place at the cell surface or in endolysos...
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| Veröffentlicht in: | J Biol Chem |
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| Hauptverfasser: | , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Society for Biochemistry and Molecular Biology
2017
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5437241/ https://ncbi.nlm.nih.gov/pubmed/28341739 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.773283 |
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