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Engulfment of cerebral apoptotic bodies controls the course of prion disease in a mouse strain–dependent manner
Progressive accumulation of PrP(Sc), a hallmark of prion diseases, occurs when conversion of PrP(C) into PrP(Sc) is faster than PrP(Sc) clearance. Engulfment of apoptotic bodies by phagocytes is mediated by Mfge8 (milk fat globule epidermal growth factor 8). In this study, we show that brain Mfge8 i...
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| Main Authors: | , , , , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
The Rockefeller University Press
2010
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2947076/ https://ncbi.nlm.nih.gov/pubmed/20837697 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20092401 |
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