Engulfment of cerebral apoptotic bodies controls the course of prion disease in a mouse strain–dependent manner

Progressive accumulation of PrP(Sc), a hallmark of prion diseases, occurs when conversion of PrP(C) into PrP(Sc) is faster than PrP(Sc) clearance. Engulfment of apoptotic bodies by phagocytes is mediated by Mfge8 (milk fat globule epidermal growth factor 8). In this study, we show that brain Mfge8 i...

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Main Authors: Kranich, Jan, Krautler, Nike Julia, Falsig, Jeppe, Ballmer, Boris, Li, Shulei, Hutter, Gregor, Schwarz, Petra, Moos, Rita, Julius, Christian, Miele, Gino, Aguzzi, Adriano
Format: Artigo
Jezik:Inglês
Izdano: The Rockefeller University Press 2010
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2947076/
https://ncbi.nlm.nih.gov/pubmed/20837697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20092401
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