Structure of human promyeloperoxidase (proMPO) and the role of the propeptide in processing and maturation

Myeloperoxidase (MPO) is synthesized by neutrophil and monocyte precursor cells and contributes to host defense by mediating microbial killing. Although several steps in MPO biosynthesis and processing have been elucidated, many questions remained, such as the structure-function relationship of mono...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:J Biol Chem
Main Authors: Grishkovskaya, Irina, Paumann-Page, Martina, Tscheliessnig, Rupert, Stampler, Johanna, Hofbauer, Stefan, Soudi, Monika, Sevcnikar, Benjamin, Oostenbrink, Chris, Furtmüller, Paul G., Djinović-Carugo, Kristina, Nauseef, William M., Obinger, Christian
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2017
Teme:
Protein Structure and Folding
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5437232/
https://ncbi.nlm.nih.gov/pubmed/28348079
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.775031
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