Pre-steady-state Kinetics Reveal the Substrate Specificity and Mechanism of Halide Oxidation of Truncated Human Peroxidasin 1

Human peroxidasin 1 is a homotrimeric multidomain peroxidase that is secreted to the extracellular matrix. The heme enzyme was shown to release hypobromous acid that mediates the formation of specific covalent sulfilimine bonds to reinforce collagen IV in basement membranes. Maturation by proteolyti...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Paumann-Page, Martina, Katz, Romy-Sophie, Bellei, Marzia, Schwartz, Irene, Edenhofer, Eva, Sevcnikar, Benjamin, Soudi, Monika, Hofbauer, Stefan, Battistuzzi, Gianantonio, Furtmüller, Paul G., Obinger, Christian
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2017
Assuntos:
Enzymology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5377774/
https://ncbi.nlm.nih.gov/pubmed/28154175
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.775213
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