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Peroxidasin mediates bromination of tyrosine residues in the extracellular matrix

Peroxidasin is a heme peroxidase that oxidizes bromide to hypobromous acid (HOBr), a powerful oxidant that promotes the formation of the sulfilimine crosslink in collagen IV in basement membranes. We investigated whether HOBr released by peroxidasin leads to other oxidative modifications of proteins...

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Détails bibliographiques
Publié dans:J Biol Chem
Auteurs principaux: Bathish, Boushra, Paumann-Page, Martina, Paton, Louise N., Kettle, Anthony J., Winterbourn, Christine C.
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2020
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7476726/
https://ncbi.nlm.nih.gov/pubmed/32675287
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.014504
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