Structure of human promyeloperoxidase (proMPO) and the role of the propeptide in processing and maturation

Myeloperoxidase (MPO) is synthesized by neutrophil and monocyte precursor cells and contributes to host defense by mediating microbial killing. Although several steps in MPO biosynthesis and processing have been elucidated, many questions remained, such as the structure-function relationship of mono...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Grishkovskaya, Irina, Paumann-Page, Martina, Tscheliessnig, Rupert, Stampler, Johanna, Hofbauer, Stefan, Soudi, Monika, Sevcnikar, Benjamin, Oostenbrink, Chris, Furtmüller, Paul G., Djinović-Carugo, Kristina, Nauseef, William M., Obinger, Christian
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2017
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5437232/
https://ncbi.nlm.nih.gov/pubmed/28348079
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.775031
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