Structure of human promyeloperoxidase (proMPO) and the role of the propeptide in processing and maturation

Myeloperoxidase (MPO) is synthesized by neutrophil and monocyte precursor cells and contributes to host defense by mediating microbial killing. Although several steps in MPO biosynthesis and processing have been elucidated, many questions remained, such as the structure-function relationship of mono...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Grishkovskaya, Irina, Paumann-Page, Martina, Tscheliessnig, Rupert, Stampler, Johanna, Hofbauer, Stefan, Soudi, Monika, Sevcnikar, Benjamin, Oostenbrink, Chris, Furtmüller, Paul G., Djinović-Carugo, Kristina, Nauseef, William M., Obinger, Christian
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2017
Subjects:
Protein Structure and Folding
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5437232/
https://ncbi.nlm.nih.gov/pubmed/28348079
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.775031
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