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Selection and characterization of a DNA aptamer inhibiting coagulation factor XIa
Factor XIa (FXIa) is a serine protease that catalyzes the activation of Factor IX (FIX) in the blood coagulation cascade. FXIa and its precursor FXI are emergent therapeutic targets for the development of safer anticoagulant agents. Here, we sought a novel DNA-based agent to inhibit FXIa. Towards th...
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| Udgivet i: | Sci Rep |
|---|---|
| Main Authors: | , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Nature Publishing Group UK
2017
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5437010/ https://ncbi.nlm.nih.gov/pubmed/28522812 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-02055-x |
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