Selection and characterization of a DNA aptamer inhibiting coagulation factor XIa

Factor XIa (FXIa) is a serine protease that catalyzes the activation of Factor IX (FIX) in the blood coagulation cascade. FXIa and its precursor FXI are emergent therapeutic targets for the development of safer anticoagulant agents. Here, we sought a novel DNA-based agent to inhibit FXIa. Towards th...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Donkor, David A., Bhakta, Varsha, Eltringham-Smith, Louise J., Stafford, Alan R., Weitz, Jeffrey I., Sheffield, William P.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5437010/
https://ncbi.nlm.nih.gov/pubmed/28522812
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-02055-x
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