The I(K1)/Kir2.1 channel agonist zacopride prevents and cures acute ischemic arrhythmias in the rat

Arrhythmogenesis in acute myocardial infarction (MI) is associated with depolarization of resting membraine potential (RMP) and decrease of inward rectifier potassium current (I(K1)) in cardiomyocytes. However, clinical anti-arrhythmic agents that primarily act on RMP by enhancing the I(K1) channel...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Zhai, Xu-Wen, Zhang, Li, Guo, Yun-Fei, Yang, Ying, Wang, Dong-Ming, Zhang, Yan, Li, Pan, Niu, Yi-Fan, Feng, Qi-Long, Wu, Bo-Wei, Cao, Ji-Min, Liu, Qing-Hua
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5436763/
https://ncbi.nlm.nih.gov/pubmed/28542320
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0177600
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