Styrax blocks inward and outward current of Kir2.1 channel

Kir2.1 plays key roles in setting rest membrane potential and modulation of cell excitability. Mutations of Kir2.1, such as D172N or E299V, inducing gain-of-function, can cause type3 short QT syndrome (SQT3) due to the enlarged outward currents. So far, there is no clinical drug target to block the...

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Bibliografiske detaljer
Udgivet i:Channels (Austin)
Main Authors: Ren, Shuxi, Pang, Chunli, Li, Junwei, Huang, Yayue, Zhang, Suhua, Zhan, Yong, An, Hailong
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 2016
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5279881/
https://ncbi.nlm.nih.gov/pubmed/27540685
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19336950.2016.1207022
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