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Styrax blocks inward and outward current of Kir2.1 channel
Kir2.1 plays key roles in setting rest membrane potential and modulation of cell excitability. Mutations of Kir2.1, such as D172N or E299V, inducing gain-of-function, can cause type3 short QT syndrome (SQT3) due to the enlarged outward currents. So far, there is no clinical drug target to block the...
Gardado en:
| Publicado en: | Channels (Austin) |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Taylor & Francis
2016
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5279881/ https://ncbi.nlm.nih.gov/pubmed/27540685 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19336950.2016.1207022 |
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