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The molecular basis of chloroquine block of the inward rectifier Kir2.1 channel
Although chloroquine remains an important therapeutic agent for treatment of malaria in many parts of the world, its safety margin is very narrow. Chloroquine inhibits the cardiac inward rectifier K(+) current I(K1) and can induce lethal ventricular arrhythmias. In this study, we characterized the b...
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| Main Authors: | , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
2008
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2234144/ https://ncbi.nlm.nih.gov/pubmed/18216262 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0708153105 |
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