The molecular basis of chloroquine block of the inward rectifier Kir2.1 channel

Although chloroquine remains an important therapeutic agent for treatment of malaria in many parts of the world, its safety margin is very narrow. Chloroquine inhibits the cardiac inward rectifier K(+) current I(K1) and can induce lethal ventricular arrhythmias. In this study, we characterized the b...

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Tallennettuna:
Bibliografiset tiedot
Päätekijät: Rodríguez-Menchaca, Aldo A., Navarro-Polanco, Ricardo A., Ferrer-Villada, Tania, Rupp, Jason, Sachse, Frank B., Tristani-Firouzi, Martin, Sánchez-Chapula, José A.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: National Academy of Sciences 2008
Aiheet:
Biological Sciences
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2234144/
https://ncbi.nlm.nih.gov/pubmed/18216262
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0708153105
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