The molecular basis of chloroquine block of the inward rectifier Kir2.1 channel

Although chloroquine remains an important therapeutic agent for treatment of malaria in many parts of the world, its safety margin is very narrow. Chloroquine inhibits the cardiac inward rectifier K(+) current I(K1) and can induce lethal ventricular arrhythmias. In this study, we characterized the b...

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Bibliografische gegevens
Hoofdauteurs: Rodríguez-Menchaca, Aldo A., Navarro-Polanco, Ricardo A., Ferrer-Villada, Tania, Rupp, Jason, Sachse, Frank B., Tristani-Firouzi, Martin, Sánchez-Chapula, José A.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: National Academy of Sciences 2008
Onderwerpen:
Biological Sciences
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2234144/
https://ncbi.nlm.nih.gov/pubmed/18216262
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0708153105
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