Chloroquine Blocks a Mutant Kir2.1 Channel Responsible for Short QT Syndrome and Normalizes Repolarization Properties in silico

Short QT Syndrome (SQTS) is a novel clinical entity characterized by markedly rapid cardiac repolarization and lethal arrhythmias. A mutation in the Kir2.1 inward rectifier K(+) channel (D172N) causes one form of SQTS (SQT3). Pharmacologic block of Kir2.1 channels may hold promise as potential thera...

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Detalhes bibliográficos
Main Authors: Lopez-Izquierdo, Angelica, Ponce-Balbuena, Daniela, Ferrer, Tania, Sachse, Frank B., Tristani-Firouzi, Martin, Sánchez-Chapula, José A.
Formato: Artigo
Idioma:Inglês
Publicado em: S. Karger AG 2009
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Original Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3711575/
https://ncbi.nlm.nih.gov/pubmed/19710529
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000233241
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