Action potential clamp and chloroquine sensitivity of mutant Kir2.1 channels responsible for variant 3 short QT syndrome

Recently identified genetic forms of short QT syndrome (SQTS) are associated with an increased risk of arrhythmia and sudden death. The SQT3 variant is associated with an amino-acid substitution (D172N) in the KCNJ2-encoded Kir2.1 K(+) channel. In this study, whole-cell action potential (AP) clamp r...

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Detalhes bibliográficos
Main Authors: El Harchi, Aziza, McPate, Mark J., Zhang, Yi hong, Zhang, Henggui, Hancox, Jules C.
Formato: Artigo
Idioma:Inglês
Publicado em: Academic Press 2009
Assuntos:
Rapid Communication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2765655/
https://ncbi.nlm.nih.gov/pubmed/19285083
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2009.02.027
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