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Inward rectification by polyamines in mouse Kir2.1 channels: synergy between blocking components
We recently characterized two distinct mechanisms by which the polyamine spermine blocks Kir2.1 channels: (1) by reduction of negative surface charges in the cytoplasmicpore, thereby reducing single-channel conductance, and (2) by direct open channel transmembrane pore block. The extent to which the...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Blackwell Science Inc
2003
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2343018/ https://ncbi.nlm.nih.gov/pubmed/12740427 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2003.043117 |
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