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Spermine Block of the Strong Inward Rectifier Potassium Channel Kir2.1: Dual Roles of Surface Charge Screening and Pore Block

Inward rectification in strong inward rectifiers such as Kir2.1 is attributed to voltage-dependent block by intracellular polyamines and Mg(2+). Block by the polyamine spermine has a complex voltage dependence with shallow and steep components and complex concentration dependence. To understand the...

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Autori principali: Xie, Lai-Hua, John, Scott A., Weiss, James N.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Rockefeller University Press 2002
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2311403/
https://ncbi.nlm.nih.gov/pubmed/12084775
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.20028576
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