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Voltage-dependent gating and block by internal spermine of the murine inwardly rectifying K(+) channel, Kir2.1

The mechanism of inward rectification was investigated by recording single-channel currents through an inwardly rectifying K(+) channel (Kir2.1). cDNA encoding a wild-type (WT) channel, a mutant replacing Asp 172 with Asn (D172N), and a tandem tetramer WT-(D172N)2-WT, was transfected into COS-1 cell...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Matsuda, Hiroko, Oishi, Keiko, Omori, Koichiro
Format: Artigo
Sprache:Inglês
Veröffentlicht: Blackwell Science Inc 2003
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2342863/
https://ncbi.nlm.nih.gov/pubmed/12640008
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2003.038844
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