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Voltage-dependent gating and block by internal spermine of the murine inwardly rectifying K(+) channel, Kir2.1
The mechanism of inward rectification was investigated by recording single-channel currents through an inwardly rectifying K(+) channel (Kir2.1). cDNA encoding a wild-type (WT) channel, a mutant replacing Asp 172 with Asn (D172N), and a tandem tetramer WT-(D172N)2-WT, was transfected into COS-1 cell...
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| Main Authors: | , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Blackwell Science Inc
2003
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2342863/ https://ncbi.nlm.nih.gov/pubmed/12640008 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2003.038844 |
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