I(K1) Channel Agonist Zacopride Alleviates Cardiac Hypertrophy and Failure via Alterations in Calcium Dyshomeostasis and Electrical Remodeling in Rats

Intracellular Ca(2+) overload, prolongation of the action potential duration (APD), and downregulation of inward rectifier potassium (I(K1)) channel are hallmarks of electrical remodeling in cardiac hypertrophy and heart failure (HF). We hypothesized that enhancement of I(K1) currents is a compensat...

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Detalhes bibliográficos
Publicado no:Front Pharmacol
Main Authors: Liu, Qing-Hua, Qiao, Xi, Zhang, Li-Jun, Wang, Jin, Zhang, Li, Zhai, Xu-Wen, Ren, Xiao-Ze, Li, Yu, Cao, Xiao-Na, Feng, Qi-Long, Cao, Ji-Min, Wu, Bo-Wei
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6718093/
https://ncbi.nlm.nih.gov/pubmed/31507422
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2019.00929
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