NMR-based method of small changes reveals how DNA mutator APOBEC3A interacts with its single-stranded DNA substrate

APOBEC3 proteins are double-edged swords. They deaminate cytosine to uracil in single-stranded DNA and provide protection, as part of our innate immune system, against viruses and retrotransposons, but they are also involved in cancer evolution and development of drug resistance. We report a solutio...

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Bibliografske podrobnosti
izdano v:Nucleic Acids Res
Main Authors: Harjes, Stefan, Jameson, Geoffrey B., Filichev, Vyacheslav V., Edwards, Patrick J. B., Harjes, Elena
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2017
Teme:
Structural Biology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5435981/
https://ncbi.nlm.nih.gov/pubmed/28369637
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkx196
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