Differential Inhibition of APOBEC3 DNA‐Mutator Isozymes by Fluoro‐ and Non‐Fluoro‐Substituted 2′‐Deoxyzebularine Embedded in Single‐Stranded DNA

The APOBEC3 (APOBEC3A‐H) enzyme family is part of the human innate immune system that restricts pathogens by scrambling pathogenic single‐stranded (ss) DNA by deamination of cytosines to produce uracil residues. However, APOBEC3‐mediated mutagenesis of viral and cancer DNA promotes its evolution, th...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Chembiochem
Egile Nagusiak: Kvach, Maksim V., Barzak, Fareeda M., Harjes, Stefan, Schares, Henry A. M., Kurup, Harikrishnan M., Jones, Katherine F., Sutton, Lorraine, Donahue, John, D'Aquila, Richard T., Jameson, Geoffrey B., Harki, Daniel A., Krause, Kurt L., Harjes, Elena, Filichev, Vyacheslav V.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: John Wiley and Sons Inc. 2019
Gaiak:
Full Papers
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7142307/
https://ncbi.nlm.nih.gov/pubmed/31633265
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.201900505
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