The HIV-1 Vif PPLP Motif is Necessary for Human APOBEC3G Binding and Degradation

The HIV-1 virion infectivity factor (Vif) is required during viral replication to inactivate the host cell anti-viral factor, APOBEC3G (A3G). Vif binds A3G and a Cullin5-ElonginBC E3 ubiquitin ligase complex which results in the proteasomal degradation of A3G. The Vif PPLP motif (amino acids 161–164...

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Bibliografiske detaljer
Main Authors: Donahue, John P., Vetter, Michael L., Mukhtar, Nizar A., D’Aquila, Richard T.
Format: Artigo
Sprog:Inglês
Udgivet: 2008
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2474554/
https://ncbi.nlm.nih.gov/pubmed/18499212
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2008.04.017
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