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The HIV-1 Vif PPLP Motif is Necessary for Human APOBEC3G Binding and Degradation
The HIV-1 virion infectivity factor (Vif) is required during viral replication to inactivate the host cell anti-viral factor, APOBEC3G (A3G). Vif binds A3G and a Cullin5-ElonginBC E3 ubiquitin ligase complex which results in the proteasomal degradation of A3G. The Vif PPLP motif (amino acids 161–164...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2474554/ https://ncbi.nlm.nih.gov/pubmed/18499212 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2008.04.017 |
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