Substrate preference of Gen endonucleases highlights the importance of branched structures as DNA damage repair intermediates

Human GEN1 and yeast Yen1 are endonucleases with the ability to cleave Holliday junctions (HJs), which are proposed intermediates in recombination. In vivo, GEN1 and Yen1 function secondarily to Mus81, which has weak activity on intact HJs. We show that the genetic relationship is reversed in Drosop...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Bellendir, Stephanie P., Rognstad, Danielle J., Morris, Lydia P., Zapotoczny, Grzegorz, Walton, William G., Redinbo, Matthew R., Ramsden, Dale A., Sekelsky, Jeff, Erie, Dorothy A.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2017
Assuntos:
Nucleic Acid Enzymes
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5435919/
https://ncbi.nlm.nih.gov/pubmed/28369583
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkx214
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