Substrate preference of Gen endonucleases highlights the importance of branched structures as DNA damage repair intermediates

Human GEN1 and yeast Yen1 are endonucleases with the ability to cleave Holliday junctions (HJs), which are proposed intermediates in recombination. In vivo, GEN1 and Yen1 function secondarily to Mus81, which has weak activity on intact HJs. We show that the genetic relationship is reversed in Drosop...

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Vydáno v:Nucleic Acids Res
Hlavní autoři: Bellendir, Stephanie P., Rognstad, Danielle J., Morris, Lydia P., Zapotoczny, Grzegorz, Walton, William G., Redinbo, Matthew R., Ramsden, Dale A., Sekelsky, Jeff, Erie, Dorothy A.
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2017
Témata:
Nucleic Acid Enzymes
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5435919/
https://ncbi.nlm.nih.gov/pubmed/28369583
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkx214
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