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Nerve injury-induced epigenetic silencing of opioid receptors controlled by DNMT3a in primary afferent neurons
Opioids are the gold standard for pharmacological treatment of neuropathic pain, but their analgesic effects are unsatisfactory in part due to nerve injury-induced downregulation of opioid receptors in dorsal root ganglia (DRG) neurons. How nerve injury drives such downregulation remains elusive. DN...
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| Опубликовано в: : | Pain |
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| Главные авторы: | , , , , , , , , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2017
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5435541/ https://ncbi.nlm.nih.gov/pubmed/28267064 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/j.pain.0000000000000894 |
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