Nerve injury-induced epigenetic silencing of opioid receptors controlled by DNMT3a in primary afferent neurons

Opioids are the gold standard for pharmacological treatment of neuropathic pain, but their analgesic effects are unsatisfactory in part due to nerve injury-induced downregulation of opioid receptors in dorsal root ganglia (DRG) neurons. How nerve injury drives such downregulation remains elusive. DN...

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Udgivet i:Pain
Main Authors: Sun, Linlin, Zhao, Jian-Yuan, Gu, Xiyao, Liang, Lingli, Wu, Shaogen, Mo, Kai, Feng, Jian, Guo, Weixiang, Zhang, Jun, Bekker, Alex, Zhao, Xinyu, Nestler, Eric J, Tao, Yuan-Xiang
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5435541/
https://ncbi.nlm.nih.gov/pubmed/28267064
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/j.pain.0000000000000894
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