Nerve injury-induced epigenetic silencing of opioid receptors controlled by DNMT3a in primary afferent neurons

Opioids are the gold standard for pharmacological treatment of neuropathic pain, but their analgesic effects are unsatisfactory in part due to nerve injury-induced downregulation of opioid receptors in dorsal root ganglia (DRG) neurons. How nerve injury drives such downregulation remains elusive. DN...

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Veröffentlicht in:Pain
Hauptverfasser: Sun, Linlin, Zhao, Jian-Yuan, Gu, Xiyao, Liang, Lingli, Wu, Shaogen, Mo, Kai, Feng, Jian, Guo, Weixiang, Zhang, Jun, Bekker, Alex, Zhao, Xinyu, Nestler, Eric J, Tao, Yuan-Xiang
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5435541/
https://ncbi.nlm.nih.gov/pubmed/28267064
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/j.pain.0000000000000894
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