Contribution of DNMT1 to Neuropathic Pain Genesis Partially through Epigenetically Repressing Kcna2 in Primary Afferent Neurons

Expressional changes of pain-associated genes in primary sensory neurons of DRG are critical for neuropathic pain genesis. DNA methyltransferase (DNMT)-triggered DNA methylation silences gene expression. We show here that DNMT1, a canonical maintenance methyltransferase, acts as the de novo DNMT and...

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Bibliografiska uppgifter
I publikationen:J Neurosci
Huvudupphovsmän: Sun, Linlin, Gu, Xiyao, Pan, Zhiqiang, Guo, Xinying, Liu, Jianbin, Atianjoh, Fidelis E., Wu, Shaogen, Mo, Kai, Xu, Bo, Liang, Lingli, Bekker, Alex, Tao, Yuan-Xiang
Materialtyp: Artigo
Språk:Inglês
Publicerad: Society for Neuroscience 2019
Ämnen:
Research Articles
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6697395/
https://ncbi.nlm.nih.gov/pubmed/31182635
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0695-19.2019
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