DNA methyltransferase DNMT3a contributes to neuropathic pain by repressing Kcna2 in primary afferent neurons

Nerve injury induces changes in gene transcription in dorsal root ganglion (DRG) neurons, which may contribute to nerve injury-induced neuropathic pain. DNA methylation represses gene expression. Here, we report that peripheral nerve injury increases expression of the DNA methyltransferase DNMT3a in...

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Publicat a:Nat Commun
Autors principals: Zhao, Jian-Yuan, Liang, Lingli, Gu, Xiyao, Li, Zhisong, Wu, Shaogen, Sun, Linlin, Atianjoh, Fidelis E., Feng, Jian, Mo, Kai, Jia, Shushan, Lutz, Brianna Marie, Bekker, Alex, Nestler, Eric J., Tao, Yuan-Xiang
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2017
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5344974/
https://ncbi.nlm.nih.gov/pubmed/28270689
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms14712
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