DNA methyltransferase DNMT3a contributes to neuropathic pain by repressing Kcna2 in primary afferent neurons

Nerve injury induces changes in gene transcription in dorsal root ganglion (DRG) neurons, which may contribute to nerve injury-induced neuropathic pain. DNA methylation represses gene expression. Here, we report that peripheral nerve injury increases expression of the DNA methyltransferase DNMT3a in...

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Publicado no:Nat Commun
Main Authors: Zhao, Jian-Yuan, Liang, Lingli, Gu, Xiyao, Li, Zhisong, Wu, Shaogen, Sun, Linlin, Atianjoh, Fidelis E., Feng, Jian, Mo, Kai, Jia, Shushan, Lutz, Brianna Marie, Bekker, Alex, Nestler, Eric J., Tao, Yuan-Xiang
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5344974/
https://ncbi.nlm.nih.gov/pubmed/28270689
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms14712
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